KMID : 1143920180220040297
|
|
Annals of Hepato-Biliary-Pancreatic Surgery 2018 Volume.22 No. 4 p.297 ~ p.304
|
|
Absence of antitumor effects of metformin in sorafenib-treated patients with hepatocellular carcinoma recurrence after hepatic resection and liver transplantation
|
|
Chung Yong-Kyu
Hwang Shin Song Gi-Won Lee Young-Joo Kim Ki-Hun Ahn Chul-Soo Moon Deok-Bog Ha Tae-Yong Jung Dong-Hwan Park Gil-Chun Ryoo Baek-Yeol Lee Sung-Gyu
|
|
Abstract
|
|
|
Backgrounds/Aims: Hepatocellular carcinoma (HCC) recurrence following hepatic resection (HR) and liver transplantation (LT) remains a great concern. We assessed the antitumor effects of metformin in patients treated with sorafenib for HCC recurrence after HR or LT.
Methods: The two clinical retrospective studies involved metformin therapy of 304 HR patients and 74 LT recipients who were treated with sorafenib.
Results: In the study involving patients who had undergone HR, death occurred in 245 of the 304 patients (80.6%) during a median follow-up of 10.2 months after sorafenib administration. The metformin HR group (group 1; n=40) showed no prognostic difference in progression-free and overall survival rates compared with the all-HR control group (group 3; n=241) and propensity score-matched HR control group (group 4; n=80). In the clinical study of recipients exposed to LT, death occurred in 62 of the 74 patients (83.8%) during a median follow-up of 13.6 months (range: 3-76 months) after sorafenib administration. The metformin LT group (group 5; n=14) showed no prognostic difference in progression-free and overall survival rates compared with the all-LT control group (group 7; n=43) and propensity score-matched LT control group (group 8; n=28).
Conclusions: Our clinical studies demonstrated absence of synergistic antitumor effects of metformin. Further high-volume studies are necessary to assess the role of metformin in patients treated with sorafenib for advanced HCC.
|
|
KEYWORD
|
|
Diabetic mellitus, Hepatic resection, Metformin, Recurrence
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|